GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs1027730 | 1 | rs6982238 | chr8:94069299 | C8orf83 | chr8:93895865-94029901:- | 0.3 | 4.75 | 2.65E-6 | Attention deficit hyperactivity disorder |
| THCA | cis | rs6982751 | 1 | rs6982751 | chr8:10813474 | CTSB | chr8:11700036-11725646:- | 0.22 | 3.5 | 0.000501 | Asthma and hay fever |
| THCA | cis | rs6982751 | 1 | rs6982927 | chr8:10813598 | CTSB | chr8:11700036-11725646:- | 0.22 | 3.5 | 0.000501 | Asthma and hay fever |
| THCA | cis | rs6988636 | 1 | rs6983795 | chr8:124185296 | FAM83A | chr8:124191287-124222317:+ | -0.34 | -4.19 | 3.33E-5 | Urinary uromodulin levels |
| THCA | cis | rs55821258 | 1 | rs6984009 | chr8:96289091 | C8orf37 | chr8:96258235-96281437:- | 0.31 | 4.11 | 4.67E-5 | 3-hydroxy-1-methylpropylmercapturic acid levels in smokers |
| THCA | cis | rs783540 | 1 | rs698500 | chr15:83237769 | CPEB1 | chr15:83211952-83316728:- | -0.17 | -3.69 | 0.00025 | Schizophrenia |
| THCA | cis | rs783540 | 1 | rs698500 | chr15:83237769 | GOLGA6L9 | chr15:82711895-82731584:+;chr15 | -0.15 | -4.74 | 2.85E-6 | Schizophrenia |
| THCA | cis | rs7818688 | 1 | rs6985880 | chr8:96027599 | C8orf38 | chr8:95908040-96088396:+ | -0.25 | -4.26 | 2.48E-5 | Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia |
| THCA | cis | rs13253073 | 1 | rs6986006 | chr8:100869479 | VPS13B | chr8:100025494-100889807:+ | -0.12 | -3.56 | 0.000408 | Glucose homeostasis traits |
| THCA | cis | rs1027730 | 1 | rs6987050 | chr8:94082293 | C8orf83 | chr8:93895865-94029901:- | 0.2 | 3.37 | 0.000806 | Attention deficit hyperactivity disorder |
| THCA | cis | rs2129782 | 1 | rs6987711 | chr8:89425711 | MMP16 | chr8:89049462-89339717:- | 0.32 | 5.17 | 3.5E-7 | Electrodermal activity |
| THCA | cis | rs2129782 | 1 | rs6988021 | chr8:89450084 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs1027730 | 1 | rs6988108 | chr8:94072176 | C8orf83 | chr8:93895865-94029901:- | 0.28 | 4.45 | 1.07E-5 | Attention deficit hyperactivity disorder |
| THCA | cis | rs6988636 | 1 | rs6988636 | chr8:124185970 | FAM83A | chr8:124191287-124222317:+ | -0.32 | -4.13 | 4.19E-5 | Urinary uromodulin levels |
| THCA | cis | rs516946 | 1 | rs6989203 | chr8:41523745 | ANK1 | chr8:41510745-41754280:- | 0.23 | 4.85 | 1.68E-6 | Type 2 diabetes |